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1例63岁男性患者行二尖瓣和主动脉瓣置换术，术后第1天开始给予依诺肝素钠抗凝治疗（4000 U，2次/d皮下注射）。术前及术后第1天血小板计数均正常。术后第2天血小板计数为41×109/L，给予重组人白细胞介素11皮下注射（1.5 mg/次，1次/d）。术后第3天血小板计数为22×109/L，遂停用依诺肝素钠。术后第4、5天血小板计数分别为45×109/L、59×109/L。第6天复查，血小板计数为128×109/L。“,”A 63-year-old male patient received anticoagulation therapy with a SC injection of enoxaparin sodium 4 000 U twice daily on the first day after mitral valve and aortic valve replacement. His platelet counts were within normal range before surgery and on the first day after surgery. On day 2 after surgery,his platelet count decreased to 41 × 109/L and a SC injection of recombinant human interleukin-111. 5 mg once daily was given. On day 3 after surgery,his platelet count was 22 × 109/L. Enoxaparin sodium was withdrawn. On days 4 and 5,the platelet counts increased to 45 × 109/L and 59 × 109/L,respectively. On day 6,his platelet count was 128 × 109/L.