目的：探讨胎儿宫内生长迟缓（ＩＵＧＲ） 与５羟色胺含量的关系，方法：采用ＲＦ５０００ 型荧光分光光度计测量法测量正常体重组与ＩＵＧＲ组脐静脉、脐动脉血浆中５ＨＴ 含量。结果：正常新生儿体重组及ＩＵＧＲ，脐静脉、脐动脉之间血浆中５ＨＴ 含量无明显差异（Ｐ＞ ０－０５）ＩＵＧＲ 组脐静脉、脐动脉血浆中５ＨＴ 含量明显高于正常体重组，而且差异非常显著（Ｐ＜ ０－０１）结论：ＩＵＧＲ 脐血管痉挛与５ＨＴ 含量有密切关系。在孕期ＩＵＧＲ给予扩张脐血管治疗非常重要。 Objective: To investigate the relationship between fetal intrauterine growth retardation (IUGR) and serotonin content.METHODS: The content of 5HT in umbilical vein and umbilical artery of normal weight group and IUGR group was measured by RF5000 fluorescence spectrophotometer . Results: There was no significant difference in the content of 5HT in plasma between normal newborn body weight group and IUGR, umbilical vein and umbilical artery (P> 0-05). The content of 5HT in umbilical vein and umbilical artery of IUGR group was significantly higher than that of normal Body weight, and the difference was significant (P <0-01) Conclusion: IUGR umbilical vasospasm and 5  HT content is closely related. It is important that IUGR be given dilation of umbilical cord blood during pregnancy.