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目的探讨血清胱抑素C、随机尿微量白蛋白/肌酐比值在儿童肾脏损伤中的诊断价值。方法选取45名患儿为观察组,根据疾病种类将其分为肾脏疾病组和肾外疾病组。30例健康体检儿童为对照组。分别检测血清胱抑素C(SCys C)、尿素氮(BUN)、血清肌酐(SCr)、尿肌酐及尿微量白蛋白。结果肾脏疾病组、肾外疾病组SCys C与对照组之间比较差异均有统计学意义(P<0.01);随机尿微量白蛋白与尿肌酐比值(microalbumin/creatinine ratio in random u-rine,U-mAlb/Cr)在肾外疾病组与对照组比较差异有统计学意义(P<0.01)。结论 SCys C、U-mAlb/Cr对肾脏损伤的敏感性优于传统指标BUN、SCr、eGFR及尿常规。SCys C和U-mAlb/Cr联合检测更有助于肾脏损伤病因分析及提高其阳性诊断率。
Objective To investigate the diagnostic value of serum cystatin C and random urine microalbumin / creatinine ratio in children with kidney injury. Methods 45 children were selected as observation group, which were divided into kidney disease group and renal disease group according to disease types. Thirty healthy children were taken as control group. Serum levels of Cystatin C, BUN, SCr, urinary creatinine and microalbuminuria were measured. Results There was significant difference between SCYS C group and control group in renal disease group and extrarenal disease group (P <0.01). The ratio of microalbumin / creatinine ratio in random u-rine (U -mAlb / Cr) in the extra-renal disease group compared with the control group, the difference was statistically significant (P <0.01). Conclusion The sensitivity of SCys C and U-mAlb / Cr to renal injury is better than that of traditional indicators BUN, SCr, eGFR and urinary routine. SCys C and U-mAlb / Cr combined detection is more helpful for the analysis of etiology of renal injury and improve the positive diagnosis rate.