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目的:研究50例涎腺腺样囊性癌(salivaryadenoidcysticcarcinoma,SACC)患者的肿瘤部位、临床分期、组织学分型及肿瘤转移抑制基因nm23、组织蛋白酶D(Cathepsin-D,Cath-D)、金属硫因蛋白(metalothionein,MT)、增殖细胞核抗原(proliferatingcelnuclearantigen,PCNA)、肿瘤抑制基因p53的关系。方法:用免疫组织化学反应进行多因素分析,探讨它们与局部复发、远处转移和生存率的关系。结果:影响SACC局部复发的因素太多,以上各指标均不能独立判断SACC的局部复发情况;nm23和Cath-D与SACC远处转移有明显相关性(P<0.05),表明nm23和Cath-D在SACC远处转移中具有重要作用,是预测SACC远处转移的两项独立指标;临床分期与SACC患者的生存率有明显相关性(P<0.05)。结论:临床分期可作为一项独立作用的指标来评价SACC患者的预后。
Objective: To study the tumor site, clinical stage, histological type, tumor metastasis suppressor gene nm23, cathepsin D (Cath-D), metal sulfur in 50 patients with salivary adenoid cystic carcinoma (SACC). The relationship between protein (metalothione, MT), proliferating cell nuclear antigen (PCNA) and tumor suppressor gene p53. METHODS: Multivariate analysis was performed using immunohistochemistry to investigate their relationship with local recurrence, distant metastasis, and survival. RESULTS: There were too many factors affecting the local recurrence of SACC. The above indicators could not independently judge the local recurrence of SACC; nm23 and Cath-D were significantly correlated with the distant metastasis of SACC (P<0.05), indicating that nm23 and Cath -D plays an important role in the distant metastasis of SACC and is an independent predictor of distant metastasis of SACC. Clinical staging has significant correlation with the survival rate of SACC patients (P<0.05). Conclusion: Clinical staging can be used as an independent marker to evaluate the prognosis of SACC patients.