论文部分内容阅读
目的:研究奥沙利铂与氟尿嘧啶、亚叶酸钙联合应用治疗晚期大肠癌的疗效和毒副反应。方法:采用奥沙利铂130 mg/m~2,静滴2小时,第1天;亚叶酸钙200 mg/m~2,静滴2小时,第1～5天;氟尿嘧啶300 mg/m~2(≤500mg/d),静滴4小时,第1～5天(亚叶酸钙滴完后用);21或28天为1周期。结果:总有效率为29.7%,毒副反应以骨髓抑制、感觉性神经毒性为主,白细胞减少45.9%,Ⅲ级和Ⅳ级为8.1%,感觉性神经毒性81.1%,Ⅲ级和Ⅳ级为5.4%。结论:奥沙利铂与氟尿嘧啶、亚叶酸钙联合应用治疗晚期大肠癌疗效肯定,毒副反应能耐受。
Objective: To study the curative effect and toxicity of oxaliplatin combined with fluorouracil and leucovorin in the treatment of advanced colorectal cancer. Methods: Oxaliplatin was administered intravenously for 2 hours at the dose of 130 mg / m ~ 2 for 2 hours on the first day. Leucovorin 200 mg / m ~ 2 (≤ 500mg / d), intravenous infusion of 4 hours, the first 1 to 5 days (leucovorin drops after use); 21 or 28 days for the 1 cycle. Results: The total effective rate was 29.7%. The main adverse reactions were myelosuppression and sensory neurotoxicity. The leukopenia was 45.9%, grade Ⅲ and Ⅳ were 8.1%, sensory neurotoxicity was 81.1%, grade Ⅲ and Ⅳ were 5.4%. Conclusion: The combination of oxaliplatin, fluorouracil and leucovorin is effective in the treatment of advanced colorectal cancer with tolerable side effects.