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目的研究新生儿缺氧缺血性脑病(HIE)患儿血清中IL-18水平变化,为临床提供一种新的监测指标。方法足月HIE患儿30名,轻度HIE15名,中重度HIE15名,15名非HIE为对照组。采用ELISA法测血清IL-18浓度。结果生后第3、第7天,对照组IL-18低于患病组。轻度HIE组低于中重度HIE。结论IL—18参与HIE病理过程;动态测定IL-18可判断HIE病情轻重及病程预后。
Objective To study the changes of serum IL-18 levels in neonates with hypoxic-ischemic encephalopathy (HIE) and provide a new monitoring index for clinical practice. Methods Thirty HIE infants were enrolled in this study, 15 mild HIE, 15 moderate HIE and 15 non HIE as controls. Serum IL-18 concentration was measured by ELISA. Results On the 3rd and 7th day after birth, IL-18 in the control group was lower than that in the control group. Mild HIE group was lower than moderate to severe HIE. Conclusion IL-18 is involved in the pathological process of HIE. The dynamic determination of IL-18 can determine the severity of HIE and the prognosis of HIE.