近年来重症肌无力(MG)的研究取得很大进展,但有些问题如血中抗胆碱受体(NAChR)抗体浓度与症状严重度间的关系仍有争议,应用MG模型评价药物的疗效报告极少。本文以简便可靠的方法从我国丁氏双鳍电鳐电器官中分离纯化受体膜微囊,成批免疫家兔,造成MG模型,研究病理变化,并报告我国首次从石杉科植物提取的新类型胆碱酯酶抑制剂福定碱的疗效。 In recent years, great progress has been made in the study of myasthenia gravis (MG). However, some problems such as the relationship between the blood concentration of anticholinergic receptor (NAChR) antibody and the severity of symptoms remain controversial. The MG model is used to evaluate the curative effect of drugs Very few. In this paper, a simple and reliable method to isolate and purify the receptor membrane microcapsules from the electric organ of Dictyx bipinnata in China and immunized rabbits in batches, resulting in MG model to study the pathological changes, and reported for the first time in China extracted from the genus Huperziaceae Therapeutic effect of a new type of cholinesterase inhibitor, furadine.