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目的探讨鳞状细胞癌(SCC)、神经特异性烯醇酶(NSE)、癌胚抗原(CEA)及血清细胞角蛋白19片段(CYFRA21-1)四项肿瘤标志物联合检测对肺癌的诊断价值。方法选取2010-2014年120例肺癌患者作为观察组,另选取50例良性肺部疾病患者作为对照组。比较两组患者SCC、NSE、CEA及CYFRA21-1水平,并分析不同病理类型SCC、NSE、CEA及CYFRA21-1水平及联合检测阳性率。结果观察组患者SCC、NSE、CEA及CYFRA21-1水平均高于对照组,差异有统计学意义(P<0.05);小细胞癌患者SCC、CEA、CYFRA21-1水平低于非小细胞癌患者,NSE水平明显高于非小细胞癌患者,差异有统计学意义(P<0.05);四项联合检测诊断肺癌阳性率明显高于单项检测阳性率,差异有统计学意义(P<0.05)。结论 SCC、NSE、CEA、CYFRA21-1四项肿瘤标志物联合检测可提高肺癌患者阳性检出率。
Objective To investigate the diagnostic value of combined detection of four tumor markers of squamous cell carcinoma (SCC), neuroendocrine enolase (NSE), carcinoembryonic antigen (CEA) and serum cytokeratin 19 fragment (CYFRA21-1) . Methods 120 cases of lung cancer from 2010 to 2014 were selected as observation group and 50 cases of benign lung disease were selected as control group. The levels of SCC, NSE, CEA and CYFRA21-1 were compared between the two groups. The levels of SCC, NSE, CEA and CYFRA21-1 in different pathological types and the positive rate of combined detection were analyzed. Results The levels of SCC, NSE, CEA and CYFRA21-1 in the observation group were significantly higher than those in the control group (P <0.05). The levels of SCC, CEA and CYFRA21-1 in patients with small cell carcinoma were lower than those in patients with non-small cell carcinoma (P <0.05). The positive rate of NSCLC in diagnosing lung cancer was significantly higher than that of single detection (P <0.05). Conclusion The combined detection of four tumor markers, SCC, NSE, CEA and CYFRA21-1 can improve the positive rate of lung cancer patients.