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目的 :探索部分液体通气对内毒素急性肺损伤的治疗效果。方法 :16只 SD大鼠经颈静脉注射内毒素制成急性肺损伤模型后 ,随机分为两组 :急性肺损伤 (AL I)组和部分液体通气 (PL V)组。所有动物行机械通气 ,PL V组在注射内毒素 30 min后经气管插管给予氟碳液 ,剂量 10 ml/ kg,造成 AL I,在 6 h内测定血气、血流动力学和外周血白细胞计数 ,实验结束后取肺作病理检查。结果 :两组对循环功能无明显影响 ,PL V可改善内毒素引起的 Pa O2 和 p H下降 ,病理显示部分液体通气时肺间质及肺泡毛细血管扩张不明显 ,仅有少量的炎性细胞浸润。结论 :急性肺损伤的大鼠行部分液体通气能够显著改善气体交换 ,减轻肺部炎性浸润
Objective: To explore the therapeutic effect of some liquid ventilation on endotoxin acute lung injury. Methods: Twenty-six SD rats were injected with endotoxin through the jugular vein to establish the model of acute lung injury. They were randomly divided into two groups: acute lung injury (ALI) group and partial fluid ventilation (PLV) group. All animals underwent mechanical ventilation. PL V group was given fluorocarbon solution via endotracheal intubation for 30 min after injection of endotoxin, at a dose of 10 ml / kg, resulting in ALI. Blood gas, hemodynamics and peripheral blood leukocytes Count the lungs after the experiment for pathological examination. Results: The two groups had no significant effect on the circulatory function. PL V could improve the decrease of Pa O2 and p H induced by endotoxin. The pathology showed that the pulmonary interstitial and alveolar capillary dilatation was not obvious in some liquid ventilation, only a few inflammatory cells infiltration. CONCLUSION: Partial liquid ventilation in rats with acute lung injury can significantly improve gas exchange and reduce pulmonary inflammatory infiltration