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近年来临床治疗上已广泛运用黄連或小蘖硷(黄連素)治疗各种細菌感染的疾患。它們对溶血性鏈球菌、肺炎双球菌、金色葡萄球菌、志賀氏痢疾桿菌、福氏痢疾桿菌及大肠桿菌等均有强大的抗菌作用。但是,黄連及小蘖硷口服剂量大,味苦,收效較慢,对不能口服和需要急速治疗的患者感到不便。为此,作者等拟將鹽酸小蘖硷精制成可供注射之用的注射剂。經过一段时間的摸索,已經試制成功鹽酸小蘖硷純品,其0.1%水溶液,用紙上色层分离法証明其純度与进口的E.Merck的純品完全相同。該注射液曾先后数次进行
In recent years, clinical treatment has been widely used in the treatment of various bacterial infections of Coptis or small peony (berberine). They have strong antibacterial effects on hemolytic streptococcus, Streptococcus pneumoniae, Staphylococcus aureus, Shigella dysenteriae, Shigella flexneri, and Escherichia coli. However, oral administration of Coptis chinensis and Coptis chinense has a large oral dose, a bitter taste, and a slower effect. It is inconvenient for patients who cannot take orally and need rapid treatment. For this reason, the authors and others plan to make the small hydrazine hydrochloride into injections for injection. After a period of trial and error, the successful production of a 0.1% aqueous solution of oxalic acid hydrochloride has been successfully trialed. The purity of the solution was confirmed by paper chromatographic methods identical to that of the imported E. Merck product. The injection has been carried out several times