Research concerning senescence has become a hotspot since the conception of‘cellular senescence’was put forward by Drs.Hayflick and Moorhead over five decades ago[1].Recently,a paper published in Science by Kang and colleagues,which this article aims to comment on,provides evidence of a new pathway involved in senescence[2].Senescence is a physiological and pathological process induced by numerous factors,during which cell growth ceases Research involved senescence has become a hotspot since the conception of’cellular senescence’was put forward by Drs.Hayflick and Moorhead over five decades ago [1] .Recently, a paper published in Science by Kang and colleagues, which this article aims to comment on, provides evidence of a new pathway involved in senescence [2]. Senescence is a physiological and pathological process induced by numerous factors, during which cell growth ceases