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目的:探讨血清总胆红素水平(TBIL)与冠状动脉(冠脉)内药物洗脱支架置入术后发生支架内再狭窄的相关性。方法:回顾分析719例行冠脉支架术患者资料。所有患者均于中国医科大学盛京医院复查冠脉造影,按复查造影结果分为再狭窄组(157例)及非再狭窄组(562例),记录PCI术前、术后3d及复查造影时血清TBIL及其他生化指标,并记录PCI术相关资料及再狭窄发生情况。结果:无论是PCI术前、术后以及复查造影时,再狭窄组患者的血清TBIL水平均低于非再狭窄组[术前:(12.13±4.72)μmol/L︰(12.42±5.31)μmol/L;术后:(10.96±4.63)μmol/L︰(12.29±5.30)μmol/L;复查时:(9.96±4.59)μmol/L︰(12.00±5.24)μmol/L;P<0.05];经多因素COX回归分析显示,血清TBIL是药物洗脱支架内再狭窄的独立预测因子(P<0.05)。结论:血清TBIL与支架内再狭窄的发生密切相关,高血清TBIL是冠脉内药物洗脱支架术后发生再狭窄的独立保护因素。
Objective: To investigate the relationship between serum total bilirubin level (TBIL) and in-stent restenosis after coronary stent implantation. Methods: The data of 719 patients undergoing coronary stenting were retrospectively analyzed. All patients underwent coronary angiography at Shengjing Hospital of China Medical University. According to the results of retrospective angiography, they were divided into two groups: restenosis group (157 cases) and non-restenosis group (562 cases) Serum TBIL and other biochemical indicators, and record PCI related information and the occurrence of restenosis. Results: The serum levels of TBIL in restenosis group were significantly lower than those in non-restenosis group (preoperative: (12.13 ± 4.72) μmol / L, (12.42 ± 5.31) μmol / L; (12.9 ± 4.54) μmol / L; (12.00 ± 5.24) μmol / L, respectively; P <0.05] Multivariate Cox regression analysis showed that serum TBIL was an independent predictor of restenosis in drug-eluting stents (P <0.05). Conclusion: Serum TBIL is closely related to in-stent restenosis. High-serum TBIL is an independent protective factor of restenosis after coronary stenting.