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目的探讨外周血清瘦素和肿瘤坏死因子-a(TNF-α)在妊娠期高血压疾病(HDCP)发病中的作用及其相关性。方法分别采用放免法测定60例HDCP患者与20例健康晚孕妇女(对照组)血清瘦素和TNF-α水平。结果①轻度、重度子痫前期组血清瘦素和TNF-α水平较对照组显著升高(P<0.01);②HDCP组血清瘦素和TNF-α水平之间呈显著直线正相关(P<0.01)。结论瘦素和TNF-α参与妊娠期高血压疾病发病,动态监测瘦素和TNF-α水平对预测其病情、指导临床治疗有重要意义。
Objective To investigate the role and correlation of serum leptin and tumor necrosis factor-α (TNF-α) in the pathogenesis of HDCP. Methods The levels of serum leptin and TNF-α in 60 HDCP patients and 20 healthy pregnant women (control group) were measured by radioimmunoassay. Results ① The levels of serum leptin and TNF-α in mild preeclampsia group were significantly higher than those in control group (P <0.01); ② There was a significant positive correlation between serum leptin and TNF-α level in HDCP group (P < 0.01). Conclusions Leptin and TNF-α are involved in the pathogenesis of hypertensive disorder complicating pregnancy. Dynamic monitoring of leptin and TNF-α levels is of great significance in predicting their condition and guiding clinical treatment.