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2,3,7,8-四氯二苯对二(口恶)英(TCDD)是毒性极强的环境污染物。亚中毒剂量的TCDD可引起胎鼠畸形。本文以致畸胎作用为指标,研究PCBs异构物2,3,4,5,3′,4′-六氯联苯(HCBt)和2,4,5,2′,4′,5′-六氯联苯(HCB_2)对TCDD诱发胎鼠畸形的影响。实验选用C_(57)BL/6 N品系小鼠,饲料和饮水自由摄取,交配前适应2周。然后,2雌/1雄同笼过夜,次日晨检查阴栓,阳性者定为妊娠0天。妊娠小鼠管饲投给TCDD和PCB异
2,3,7,8-tetrachlorodibenzo-p-dioxins (TCDD) is a highly toxic environmental pollutant. Sub-toxic dose of TCDD can cause fetal rat deformity. In this paper, teratogenic effects as an indicator of PCBs isomers 2,3,4,5,3 ’, 4’-hexachlorobiphenyl (HCBt) and 2,4,5,2’, 4 ’, 5’- Effect of Hexachlorobiphenyl (HCB_2) on TCDD - induced Fetal Deformity in Fetal Rats. The experiment selected C_ (57) BL / 6 N strain mice, feed and water intake, adapted to adapt before 2 weeks. Then 2 female / 1 male same cage overnight, the next morning to check the vaginal suppository, the positive was defined as 0 days of pregnancy. Pregnancy mice given TCDD and PCB tube variant