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微小RNA(microRNA,miRNA)是一类长度为21-25nt的非编码RNA,在正常细胞中参与调控细胞增殖、分化和凋亡等过程,近年研究发现它与肿瘤的发生发展密切相关。肝细胞癌(HCC)目前是全球范围内死亡率较高的癌症之一,研究提示血清microRNA有可能作为肝细胞癌的早期诊断标志物。本文综述了血清microRNA在乙型肝炎病毒(HBV)相关肝细胞癌(HBV-HCC)进展过程中的作用及其作为HBV-HCC早期诊断标志物的最新研究进展,为进一步深入研究奠定基础。
MicroRNAs (miRNAs) are a class of non-coding RNAs of 21-25 nt in length. They are involved in the regulation of cell proliferation, differentiation and apoptosis in normal cells. Recent studies show that miRNAs are closely related to tumorigenesis. Hepatocellular carcinoma (HCC) is currently one of the cancers with high mortality worldwide. Studies suggest that serum microRNAs may be used as early diagnostic markers of hepatocellular carcinoma. This review summarizes the role of serum microRNAs in the progress of hepatitis B virus (HBV) -related hepatocellular carcinoma (HBV-HCC) and its recent progress as an early diagnostic marker of HBV-HCC, which lays the foundation for further study.