胃癌作为1种严重威胁人民健康的消化道恶性肿瘤疾病,在我国年发病率占世界总发病率的42%[1]。近几年,伴随着人们对胃癌生物学行为以及发病机制的研究不断深入,我们逐渐认识到胃癌的发生、发展与癌基因的激活和抑癌基因的失活密切相关[2],其中,抑癌基因PTEN在这一恶性肿瘤的形成与进展 Gastric cancer as a serious threat to people’s health of gastrointestinal cancer, annual incidence in China accounted for 42% of the world’s incidence [1]. In recent years, along with the continuous research on the biological behaviors and pathogenesis of gastric cancer, we have come to realize that the occurrence and development of gastric cancer are closely related to the activation of oncogenes and the inactivation of tumor suppressor genes [2]. Among them, Oncogene PTEN in the formation and progression of this malignant tumor