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目的:探讨孕足月胎膜早破孕妇联合检测外周血降钙素原、超敏C-反应蛋白水平,结合白细胞计数及胎盘病理对预测绒毛膜羊膜炎价值,并指导抗生素的合理应用。方法:选取本院60例孕周37周至40周胎膜早破孕妇作为观察组,同期产检且孕周相同的60例无产科合并症孕妇作为对照组,采用荧光定量法检测血清降钙素原,免疫层析法检测血清超敏C-反应蛋白,并检测孕妇白细胞计数,结合胎盘病理检查,比较两组降钙素原和超敏C反应蛋白水平及绒毛膜羊膜炎发生率。结果:观察组降钙素原和超敏C-反应蛋白水平及绒毛膜羊膜炎发生率明显高于对照组,两组差异有显著性(P<0.05)。结论:联合检测胎膜早破孕妇血清降钙素原、超敏C-反应蛋白、白细胞计数能敏感预测绒毛膜羊膜炎发生,指导及时合理应用抗生素,降低对母婴的危害。
OBJECTIVE: To investigate the combined detection of peripheral blood procalcitonin and high sensitivity C-reactive protein in preterm premature rupture of membranes in pregnant women, and to predict the value of chorioamnionitis by combining the white blood cell count and placental pathology, and to guide the rational application of antibiotics. Methods: 60 pregnant women with gestational age of 37 weeks to 40 weeks in premature rupture of membranes were selected as the observation group, and 60 pregnant women with the same gestational age who underwent antenatal examination and the same gestational age were selected as the control group. Fluorescent quantitative detection of serum procalcitonin Serum C-reactive protein was detected by immunochromatography. The white blood cell count of pregnant women was detected. The placental pathological examination was used to compare the levels of procalcitonin and high-sensitivity C-reactive protein and the incidence of chorioamnionitis. Results: The levels of procalcitonin, high sensitivity C-reactive protein and chorioamnionitis in the observation group were significantly higher than those in the control group. There was significant difference between the two groups (P <0.05). Conclusion: The combined detection of serum procalcitonin, high sensitivity C-reactive protein and leukocyte count in pregnant women with premature rupture of membranes may be sensitive to the occurrence of chorioamnionitis and guide the timely and rational use of antibiotics to reduce the harm to maternal and infant.