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目的:探讨非小细胞肺癌(NSCLC)中血管内皮生长因子(VEGF)表达与肿瘤浸润和淋巴结转移的关系。方法:应用VEGF抗体,采用微波-LSAB免疫组化染色方法对78例手术切除的NSCLC进行VEGF免疫组化染色标记,并取10例正常组织对照。结果:78例NSCLC的VEGF平均为(65.8±14.3),有淋巴结转移的VEGF(2.82±1.21)表达与无淋巴结转移的VEGF(1.28±1.08)、正常对照的VEGF(1.03±1.02)比较,差异具有非常显著的统计学意义(P<0.01)。VEGF与年龄、性别、吸烟史、肿瘤大小以及病理学分级等临床病理学特性均无明显相关关系(P>0.05)。结论:NSCLC内VEGF表达强度与淋巴结转移密切相关,可作为预测NSCLC病人预后和发生转移的生物学指标之一。
Objective: To investigate the relationship between vascular endothelial growth factor (VEGF) expression and tumor invasion and lymph node metastasis in non-small cell lung cancer (NSCLC). Methods: 78 cases of surgically resected NSCLC were immunohistochemically stained with VEGF antibody using microwave-LSAB immunohistochemical staining, and 10 cases of normal tissue were taken as control. Results: The average VEGF of 78 cases of NSCLC was (65.8 ± 14.3), VEGF (2.82 ± 1.21) with lymph node metastasis was significantly higher than that of VEGF without lymph node metastasis (1.28 ± 1.08) and normal control (1.03 ± 1.02) Has a very significant statistical significance (P <0.01). There was no significant correlation between VEGF and clinicopathological characteristics such as age, sex, smoking history, tumor size and pathological grade (P> 0.05). Conclusion: The expression of VEGF in NSCLC is closely related to the lymph node metastasis, which can be used as one of the biological indexes to predict the prognosis and metastasis of NSCLC.