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目的 探讨HBVe抗原抗体系统与丁型肝炎病毒感染的关系。方法 将 667例乙肝表面抗原(HBsAg)阳性患者分成e抗原 (HBeAg)阳性、抗 -HBe阳性和两者均阴性等三组进行丁型肝炎病毒 (HDV)标志物的检测和分析。结果 667例乙肝患者HDV感染 4 3例 ( 6 4 % ) ,其中HBeAg阳性组为 5 3 % ( 11/ 2 0 6) ,抗 -HBe阳性组为 10 9% ( 2 6/ 2 3 7) ,e抗原抗体均阴性组HDV为 2 3 % ( 6/ 2 2 5 )。抗 -HBe阳性组HDV感染明显升高 (P <0 0 1)。HBV从HBeAg阳性向抗 -HBe转换过程伴有HDV从HDAg阳性向抗 -HD抗体的转化。结论 HBV重叠感染HDV时 ,HDV感染或复制具有促进抗 -HBe转化的作用。同时HBV对HDV的复制也存在干扰作用。
Objective To investigate the relationship between HBVe antigen antibody system and hepatitis B virus infection. Methods 667 hepatitis B surface antigen (HBsAg) -positive patients were divided into three groups: hepatitis e antigen (HBeAg) positive, anti-HBe positive and negative in both groups for the detection and analysis of hepatitis B virus (HDV) markers. Results HDV infection in 667 hepatitis B patients was 43 (6.4%), of which 53% (11/2) in HBeAg positive patients and 109% (26/273) in anti-HBe positive patients, HDV was 23% (6/225) in patients with negative e antigen and antibody. HDV infection in anti-HBe positive group was significantly higher (P <0.01). The conversion of HBV from HBeAg-positive to anti-HBe is accompanied by the conversion of HDV from HDAg-positive to anti-HD. Conclusion HDV infection or replication can promote anti-HBe conversion when HBV is infected with HDV. HBV replication of HDV also interfere with the role.