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目的探讨血清神经元特异性烯醇化酶(NSE)水平检测对重症手足口病患儿的诊断意义,为临床病情评估提供参考。方法 2013年1月至2014年1月收治的130例手足口病患儿为病例组,根据病情严重程度分为轻症组(n=79)和重症组(n=51);根据肠道病毒71型检测结果分为阳性组和阴性组;根据患儿的预后情况分为一般重症组(n=45)和危重组(n=6)。同时选取同期体检的健康儿童60例为对照组。分别检测两组及病例组各亚组的血清NSE水平并进行比较。结果病例组患儿血清NSE水平为(17.48±6.29)μg/L,对照组为(8.91±4.33)μg/L,差异有统计学意义(P<0.05)。重症组、轻症组患儿血清NSE水平分别为(25.01±5.66)μg/L、(14.28±4.19)μg/L,差异有统计学意义(P<0.05)。肠道病毒71型阳性与阴性患儿血清NSE水平分别为(20.83±7.49)μg/L、(14.26±4.33)μg/L,差异有统计学意义(P<0.05)。6例危重患儿与45例一般重症患儿血清NSE水平分别为(31.01±7.78)μg/L、(23.28±6.39)μg/L,差异有统计学意义(P<0.05)。结论血清NSE水平可随着手足口病病情严重程度的增加而上升,其血清水平检测有助于临床评估病情和判断预后。
Objective To investigate the diagnostic value of serum neuron-specific enolase (NSE) in children with severe hand-foot-mouth disease and provide a reference for clinical evaluation. Methods A total of 130 cases of HFMD were enrolled in this study from January 2013 to January 2014. The patients were divided into mild group (n = 79) and severe group (n = 51) according to the severity of the disease. 71 test results were divided into positive group and negative group; according to the prognosis of children were divided into general severe group (n = 45) and critically ill group (n = 6). At the same time select the same period the physical examination of 60 healthy children as the control group. The levels of serum NSE in each subgroup of two groups and the case group were detected and compared. Results The level of serum NSE was 17.48 ± 6.29 μg / L in the case group and 8.91 ± 4.33 μg / L in the control group. The difference was statistically significant (P <0.05). Serum levels of NSE in severe and mild group were (25.01 ± 5.66) μg / L and (14.28 ± 4.19) μg / L respectively, with statistical significance (P <0.05). The serum levels of NSE in positive and negative children with enterovirus 71 were (20.83 ± 7.49) μg / L and (14.26 ± 4.33) μg / L, respectively, with statistical significance (P <0.05). The serum levels of NSE in 6 critically ill children and 45 normal children were (31.01 ± 7.78) μg / L and (23.28 ± 6.39) μg / L, respectively, with statistical significance (P <0.05). Conclusion The level of serum NSE may increase with the severity of HFMD. The serum level of NSE may be helpful to evaluate the clinical condition and prognosis.