论文部分内容阅读
据最新一期《自然·方法学》杂志网络版报道,加拿大多伦多大学研究人员开发出一种研究人体蛋白质的新技术。该技术可追踪膜蛋白与其他蛋白之间的相互作用。膜蛋白占人体所有蛋白的约三分之一,有500多种疾病与其失能相关。膜蛋白的研究难点在于,要了解其作用,必须基于对其与其他蛋白相互作用的观察。多伦多大学细胞与生物分子研究中心教授伊戈尔·斯坦戈利亚称,新技术为检视人体细胞自然环境中的膜蛋白提供了新工具。其灵敏度足以检测到引入药物的微量变化,因此对癌症及神经疾病治疗方法的研发具有重要意义。
According to the latest edition of the journal Nature / Methodology, researchers at the University of Toronto in Canada have developed a new technique for studying human proteins. This technique tracks the interaction of membrane proteins with other proteins. Membrane proteins make up about one third of all human proteins and more than 500 diseases are associated with their disability. The challenge with membrane proteins is that to understand their role, one must base their observation on their interaction with other proteins. Igor Stanggulia, a professor at the Center for Cell and Biomolecular Research at the University of Toronto, said the new technology provides a new tool for examining membrane proteins in the natural environment of human cells. Its sensitivity is sufficient to detect trace changes in the introduction of drugs and is therefore of great importance for the development of treatments for cancer and neurological diseases.