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目的观察莫沙必利联合兰索拉唑治疗反流性食管炎的临床疗效。方法选择2010年2月至2012年5月在我院门诊及住院诊治的反流性食管炎患者67例。所有患者均给予莫沙必利5 mg餐前30 min口服,3次/d,连用8周。口服兰索拉唑30 mg,1次/d,连续服用8周。均于给药4周后和8周后评定疗效。结果 67例患者中,经过4周的治疗后,总有效率为68.7%;治疗8周后观察,总有效率为92.3%。4周与8周的疗效对比,8周疗效显著优于4周(P<0.05)结论莫沙必利联合兰索拉唑治疗RE临床效果显著,是治疗RE的有效手段,值得临床推广使用。
Objective To observe the clinical efficacy of mosapride and lansoprazole in the treatment of reflux esophagitis. Methods A total of 67 patients with reflux esophagitis who were diagnosed and treated in our hospital from February 2010 to May 2012 were selected. All patients were given mosapride 5 mg 30 min before meals orally, 3 times / d, once every 8 weeks. Lansoprazole 30 mg once daily for 8 weeks. Four weeks after administration and eight weeks after the assessment of efficacy. Results 67 patients, after 4 weeks of treatment, the total effective rate was 68.7%; 8 weeks after treatment, the total effective rate was 92.3%. Conclusion The efficacy of mosapride combined with lansoprazole in the treatment of RE has significant clinical effect and is an effective treatment for RE, which is worthy of clinical promotion.