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该研究以培养人体血管平滑肌细胞（ＶＳＭＣ）为模型，用３Ｈ－ＴｄＲ掺入试验观察钙拮抗剂（Ｎｉｆｅｄｉｐｉｎｅ、Ａｍｌｏｄｉｐｉｎｅ）和ＡＣＥＩ（Ｃｉｌａｚａｐｒｉｌ、Ｂｅｎａｚａｐｒｉｌ）对细胞增殖效应。结果３种浓度钙拮抗剂都明显抑制细胞增殖（Ｐ＜０．０１），高浓度（１０－５ｍｏｌ／Ｌ、５×１０－６ｍｏｌ／Ｌ）时Ｎｉｆｅｄｉｐｉｎｅ抑制程度更好（Ｐ＜０．０５），低浓度（１０－６ｍｏｌ／Ｌ）以Ａｍｌｏｄｉｐｉｎｅ为佳（Ｐ＜０．０５）。ＡＣＥＩ中发现高浓度时２种药物均能抑制细胞增殖（Ｐ＜０．０１），而低浓度时细胞生长反常地超过对照组（Ｐ＜０．０５）。钙拮抗剂与ＡＣＥＩ比较，前者尤其是Ｎｉｆｅｄｉｐｉｎｅ抑制细胞增殖程度较ＡＣＥＩ明显。由此推测小剂量ＡＣＥＩ反而刺激细胞增生是否与药物含量较低时仅抑制血浆ＡＣＥ活性，不能抑制组织ＡＣＥ活性有关。
In this study, cultured human vascular smooth muscle cells (VSMCs) were used as models to observe the effects of calcium antagonists (Nifedipine, Amlodipine) and ACEI (Cilazapril, Benazapril) on 3H-TdR incorporation. Results All three concentrations of calcium antagonist significantly inhibited cell proliferation (P <0.01). Nifedipine inhibited more effectively at 10-5 mol / L and 5 × 10-6 mol / L (P <0.05) (10-6mol / L) is better than Amlodipine (P <0.05). Both drugs inhibited the cell proliferation (P <0.01) at high concentrations in ACEI, while the cell growth abnormally exceeded those in the control group at low concentration (P <0.05). Calcium antagonist and ACEI compared with the former, especially Nifedipine inhibition of cell proliferation than ACEI obvious. It is inferred that low-dose ACEI but to stimulate cell proliferation and drug content is lower than only inhibit plasma ACE activity, can not inhibit ACE activity.