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目的探讨我院抗菌药物使用率及使用不合理的主要原因。方法随机抽查2005年全院各科室出院病例1315份,按设计好的项目进行回顾性调查。结果抗菌药物使用率为65.10%,无指针用药占13.55%。治疗性使用抗菌药物临床标本送检率为25.35%.一线用药占33.18%,二线用药占42.06%,三线用药占24.77%。单一用药占49.88%,二联用药占44.28%,三联用药占5.84%。手术患者一类切口平均预防用药天数为7.79天,二类切口平均预防用药天数为7.01天,三类切口平均用药天数为7.29天。术前半至两小时使用率为45.65%。结论抗菌药物的使用存在着不合理现象,使用抗菌药物应严格掌握适应症,联合用药指征,严格按照抗菌药物临床应用指导原则规范外科手术预防用药,规范抗菌药物的分线分级管理。
Objective To explore the main reasons for the use of antibacterials in our hospital and its unreasonable use. Methods A random sample of 1315 hospitalized cases in various departments of the hospital in 2005 was retrospectively investigated according to the designed projects. Results Antibacterial drug use rate was 65.10%, no pointer drug accounted for 13.55%. Therapeutic use of antimicrobial drug samples sent to clinical samples was 25.35% .First-line medication accounted for 33.18%, second-line medication accounted for 42.06%, third-line medication accounted for 24.77%. Single drug accounted for 49.88%, two drugs accounted for 44.28%, triple drug accounted for 5.84%. The mean number of days of prevention for one type of incision in patients undergoing surgery was 7.79 days, that for type II incision was 7.01 days, and that for the three types of incisions was 7.29 days on average. Half a day to two hours before use was 45.65%. Conclusion There is an irrational use of antimicrobial agents. The use of antimicrobial agents should be strictly controlled indications, combined indications, in strict accordance with the guidelines for the clinical application of antimicrobial drugs regulate the prevention of surgery to regulate the antimicrobial sub-classification management.