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目的检测慢性丙型肝炎患者和１４例ＨＣＶ原发感染后ＮＳ５抗体长达一年半的动态变化，探讨ＮＳ５抗体的临床意义。方法应用重组ＮＳ５抗原，建立ＥＩＡ方法进行检测。结果慢性丙型肝炎患者抗－ＮＳ５抗体阳性率为６０．４８％，ＨＣＶ感染后一月抗－ＮＳ５抗体阳性率为１６．３５％，三月为７５％。结论抗－ＮＳ５抗体无早期诊断价值。抗－ＮＳ５抗体持续阳性者，血清ＡＬＴ多明显升高，抗－ＮＳ５抗体与肝脏疾病活动性相关。丙型肝炎患者中存在抗－Ｃ、抗－ＮＳ３、抗－ＮＳ４抗体阴性，而抗－ＮＳ５抗体单独阳性，表明检测抗－ＮＳ５抗体具有独特的诊断价值
Objective To detect the dynamic changes of NS5 antibody in chronic hepatitis C patients and 14 cases of primary HCV infection for a year and a half, and to explore the clinical significance of NS5 antibody. Methods Recombinant NS5 antigen was used to establish EIA method. Results The positive rate of anti-NS5 antibody in patients with chronic hepatitis C was 60.48%. The positive rate of anti-NS5 antibody in January after HCV infection was 16.35% and 75% in March. Conclusion Anti-NS5 antibody has no early diagnostic value. Anti-NS5 antibodies continued to be positive, serum ALT increased significantly, anti-NS5 antibodies and liver disease activity related. Anti-C, anti-NS3, and anti-NS4 antibodies were negative in patients with hepatitis C, whereas anti-NS5 antibodies alone were positive, indicating that the detection of anti-NS5 antibodies has a unique diagnostic value