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硫酸镁有抑制横纹肌收缩的作用,是广泛用于子痫发作的治疗药物。但抑制子宫收缩,对先兆早产亦有效还未有报告。最初,Steer和Petrie报告硫酸镁对防止早产有效。他们把硫酸镁用于31例先兆早产患者,24例(77%)有效,与酒精控制组相比效果较好。Spisso等对192例先兆早产患者用硫酸镁治疗,其中未破水的119例,已破水的73例。把20克硫酸镁溶于1000毫升5%的葡萄糖液内,以每小时4.8～8.4克硫酸镁的速度静脉点滴;子宫收缩消失后改为每小时2.4克的速度静脉点滴维持12小时。把开始治疗经
Magnesium sulfate can inhibit the contraction of striated muscle function, is widely used in the treatment of eclampsia drugs. However, inhibition of uterine contractions, also effective for threatened preterm birth has not been reported. Initially, Steer and Petrie reported that magnesium sulfate is effective in preventing premature birth. They used magnesium sulfate in 31 patients with threatened preterm birth, 24 (77%) were effective and better than the alcohol-controlled group. Spisso and other 192 cases of threatened preterm delivery of patients treated with magnesium sulfate, including 119 cases of unruptured water, has been broken in 73 cases of water. 20 g of magnesium sulfate was dissolved in 1000 ml of 5% glucose solution at a rate of 4.8 to 8.4 g of magnesium sulfate per hour. After disappearance of uterine contraction, the solution was changed to an intravenous infusion of 2.4 g per hour for 12 hours. Start treatment by