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对５１例咽喉上皮增生性病变进行病理组织学观察，并应用免疫组化及ＰＣＲ方法检测人类乳头瘤病毒。其中３７例咽喉部乳头状瘤样病变分为尖锐湿疣样病变、不典型尖锐湿疣样病变、鳞状上皮乳头状瘤３组。免疫组化检测ＨＰＶ－Ａｇ：第１组阳性率３３％，后２组全部阴性。ＰＣＲ检测ＨＰＶ－ＤＮＡ：前２组全部阳性，后１组阳性率１０％。１４例喉鳞状细胞癌分为鳞状细胞疣状癌（４例）、高分化鳞状细胞癌（１０例）２组。免疫组化检测ＨＰＶ－Ａｇ：前组阴性，后组阳性率１０％；ＰＣＲ检测ＨＰＶ－ＤＮＡ：前组阳性率５０％，后组阳性率３０％。结果表明：部分咽喉上皮增生性病变的发生与ＨＰＶ感染有关。
51 cases of throat epithelial hyperplasia lesions were observed histopathologically, and immunohistochemistry and PCR detection of human papillomavirus. Thirty-seven cases of throat papilloma-like lesions were divided into genital wart-like lesions, atypical condylomata-like lesions, squamous epithelial papilloma 3 groups. HPV-Ag was detected by immunohistochemistry: the positive rate of the first group was 33%, and the second group was all negative. PCR detection of HPV-DNA: the first 2 groups were all positive, the latter group of positive rate of 10%. Fourteen cases of laryngeal squamous cell carcinoma were divided into squamous cell verrucous carcinoma (4 cases) and well differentiated squamous cell carcinoma (10 cases). Immunohistochemical detection of HPV-Ag: the former group was negative, the posterior group positive rate was 10%; PCR detection of HPV-DNA: the positive rate of the former group was 50%, the latter group of positive rate of 30%. The results showed that: the occurrence of some throat epithelial proliferative lesions and HPV infection.