胃食管反流性疾病(GORD)是一种常见病, 它可以导致多种症状,且与包括哮喘和食道腺癌在内的一些重要疾病有关遗传因素和生活方式比如吸烟,肥胖以及饮食行为都可能与GORD的发病有关胃食管相接处的结构和功能是反流性疾病发病的关键,此处的病变会导致一过性食道下端括约肌松弛,反流的风险及反流量增加如果没有报警症状,常规的内镜检查对于反流症状患者不是必需的质子泵抑制剂对大多数有典型反流症状的患者可以安全有效地长期缓解症状,但是对于不典型的症状效果较差非酸反流是导致病人对质子泵抑制剂治疗无效、症状持续的重要原因 Gastroesophageal reflux disease (GORD) is a common disease that can cause a variety of symptoms and is associated with a number of important diseases including asthma and esophageal adenocarcinoma Genetic factors and lifestyles such as smoking, obesity, and eating behavior May be related to the pathogenesis of GORD Gastroesophageal junction at the structure and function of reflux disease is the key to the disease here will lead to transient esophageal sphincter relaxation, the risk of reflux and increased reflux If there is no alarm symptoms Conventional endoscopy is not required for patients with reflux symptoms Proton pump inhibitors are safe and effective in long-term relief of symptoms for most patients with typical reflux symptoms, but are less effective in patients with atypical symptoms. Non-acid reflux is Lead to the patient proton pump inhibitor treatment ineffective, an important reason for the continued symptoms