论文部分内容阅读
1935年Williams 和Nickerson 对可能患有结节病的患者用肉芽肿组织进行皮肤试验,证明有皮肤反应,但未报告其组织学变化。1941年挪威皮肤病学者Kveim 全面描述了此试验,现命名为Kveim 试验,即给结节病患者皮内注射粗制的肉芽肿组织匀浆,几周后出现皮丘,组织学检查内含有上皮细胞肉芽肿,与结节病患者的皮疹十分相似.而对照组,包括某些结核病患者反应则为阴性。其后许多研究人员,如著名的Putkonen、Danbolt 和Nelson 用来自不同组织的粗制混悬液以证实结节组织具有
In 1935 Williams and Nickerson conducted skin tests on granulomatous tissues in patients who may have sarcoidosis, demonstrating a skin reaction but not reporting histological changes. 1941 Norwegian dermatologist Kveim fully described the trial, now named Kveim test, giving patients with sarcoidosis intradermal injection of crude granuloma tissue homogenate, a few weeks after the occurrence of pits, histological examination containing the epithelium Cell granulomas, which were similar to those in patients with sarcoidosis, were negative in controls, including in some patients with tuberculosis. Many subsequent researchers, such as the famous Putkonen, Danbolt and Nelson, used crude suspensions from different tissues to confirm that nodule tissue has