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血管内皮生长因子(vascular endothelial growth factor,VEGF)是分子量为34 000~42 000道尔顿的蛋白质。广泛分布于人体各种正常组织器官和多种肿瘤组织中,具多种生物功能,通过多种细胞表面受体和信号通路刺激内皮细胞增殖、存活、迁移,是内皮细胞生长和存活的重要因素之一~([1])。如VEGF-A主要调节血管生成和血管通透性;VEGF-C和VEGF-D
Vascular endothelial growth factor (VEGF) is a protein with a molecular weight of 34,000 to 42,000 Daltons. Widely distributed in a variety of human normal tissues and organs and a variety of tumor tissues, with a variety of biological functions, through a variety of cell surface receptors and signaling pathways to stimulate endothelial cell proliferation, survival, migration, is an important factor in endothelial cell growth and survival One ~ ([1]). Such as VEGF-A mainly regulates angiogenesis and vascular permeability; VEGF-C and VEGF-D