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目的 :观察参麦注射液对腹膜透析患者肝细胞生长因子(HGF)及腹膜功能的影响。方法 :选择2015年12月至2016年12月我院肾内科进行腹膜透析的30例患者,随机分为2组:常规腹膜透析组(对照组)和参麦注射液腹膜透析组(治疗组),每组15例。应用ELISA法检测两组HGF表达。结果 :治疗前,两组尿素清除指数(KT/V)、肌酐清除率(Ccr)、尿量和超滤量比较差异无统计学意义(P>0.05)。治疗后,对照组上述指标无显著变化(P>0.05);观察组KT/V、Ccr、尿量与治疗前比较差异无统计学意义(P>0.05),但超滤量升高(P<0.01)。治疗前,两组HGF表达水平比较差异无统计学意义(P>0.05);治疗后,对照组HGF表达无显著变化(P>0.05),但观察组显著增高(P<0.01)。结论:参麦注射液可显著提高腹透患者的超滤量,促进腹膜细胞的HGF分泌,具有抗腹膜纤维化的功效。
Objective: To observe the effect of Shenmai injection on hepatocyte growth factor (HGF) and peritoneal function in peritoneal dialysis patients. Methods: Thirty patients with peritoneal dialysis in our department from December 2015 to December 2016 were randomly divided into 2 groups: conventional peritoneal dialysis group (control group) and Shenmai injection peritoneal dialysis group (treatment group) , 15 cases in each group. HGF expression was detected by ELISA in both groups. Results: Before treatment, there was no significant difference in KT / V, Ccr, urine output and ultrafiltration volume between the two groups (P> 0.05). There was no significant difference in KT / V, Ccr and urine before and after treatment between the two groups (P> 0.05), but the amount of ultrafiltration increased (P < 0.01). Before treatment, there was no significant difference in HGF expression between the two groups (P> 0.05). After treatment, there was no significant change in HGF expression in the control group (P> 0.05), but the observation group was significantly higher (P <0.01). Conclusion: Shenmai injection can significantly increase the amount of ultrafiltration in patients with peritoneal dialysis and promote peritoneal HGF secretion, with anti-peritoneal fibrosis effect.