论文部分内容阅读
目的 :研讨FK5 0 6和环孢素A(CsA)对肾移植术后患者脂质代谢的影响。 方法 :对我们近三年以FK5 0 6或CsA为主要免疫抑制剂的肾移植患者术后 1年血脂变化进行统计及初步分析 ,明确两组患者脂质代谢的不同之处。 结果 :CsA组 (1 98例 )术后患者血脂增高的比例明显高于FK5 0 6 (36例 ,1 7 1 7%vs 2 78% ,P <0 0 5 )且CsA组血脂增高患者的手术前、后血脂水平亦有明显差异 (4 3± 1 2mmol/Lvs 4 9± 1 6mmol/L ,P <0 0 1 )。 结论 :肾移植患者术后应用FK5 0 6比CsA可以有效降低高脂血症的发病率
Objective: To investigate the effects of FK506 and cyclosporin A (CsA) on lipid metabolism in patients after kidney transplantation. Methods: The statistical analysis and primary analysis of the changes of the blood lipids in the kidney transplant recipients who received FK5 0 6 or CsA as the main immunosuppressant in the recent three years were performed to determine the difference of lipid metabolism between the two groups. Results: The increase of blood lipids in CsA group (n = 98) was significantly higher than that in FK5 0 (36 cases, 1717% vs 278%, P <0 05) and the increase of blood lipids in CsA group There was also a significant difference in serum lipids before and after treatment (4 3 ± 1 2 mmol / L vs 49 ± 1 6 mmol / L, P 0 01). Conclusion: FK5 0 6 is more effective than CsA in renal transplant recipients in reducing the incidence of hyperlipidemia