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目的观察中成药金水宝胶囊治疗早期糖尿病肾病的有效性和安全性。方法青海省人民医院2009年1月—2010年12月收治的糖尿病肾病患者90例,随机分为治疗组和对照组各45例,两组患者均采用基础治疗(包括控制血糖、血压、血脂),限制饮食,治疗组在此基础上给予金水宝胶囊6粒,3次/d口服,2个月为1个疗程。分别测定两组治疗前后Scr、FBG、HbAlc,并对各指标进行分析。结果治疗组患者生化指标及临床症状均明显改善,总有效率(86.7%),与对照组比较差异统计学意义(P<0.05)。治疗组患者尿蛋白量、Scr水平明显下降。治疗前后比较差异有统计学意义(P<0.05);对照组患者Scr水平明显下降,治疗前后比较差异有统计学意义(P<0.05),但尿蛋白量水平无明显变化;两组患者HbAlc,FBG水平均有所下降,但两组间无差异统计学意义(P>0.05)。结论金水宝胶囊治疗早期糖尿病肾病,减少蛋白尿,稳定肾功能,疗效肯定,未发现不良反应。
Objective To observe the effectiveness and safety of Chinese medicine Jin Shui Bao Capsule in the treatment of early diabetic nephropathy. Methods Ninety patients with diabetic nephropathy admitted from January 2009 to December 2010 in Qinghai Provincial People’s Hospital were randomly divided into treatment group (n = 45) and control group (n = 45). Both groups received basic treatment (including control of blood glucose, blood pressure and blood lipid) , The diet was restricted. On the basis of this, the treatment group was given 6 capsules of Jinshui Capsule, 3 times / d orally and 2 months as a course of treatment. The levels of Scr, FBG and HbAlc in both groups were measured before and after treatment, and the indexes were analyzed. Results The biochemical indexes and clinical symptoms of the treatment group were significantly improved. The total effective rate (86.7%) was significantly lower than that of the control group (P <0.05). The urinary protein level and Scr level in treatment group decreased significantly. The levels of Scr in the control group were significantly decreased (P <0.05), but there was no significant change in the level of urinary protein. The HbA1c, FBG levels decreased, but no significant difference between the two groups (P> 0.05). Conclusion Jinshuibao capsule treatment of early diabetic nephropathy, reduce proteinuria, stable renal function, positive effect, found no adverse reactions.