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已知痛觉传递调制途径之一是通过背根神经节中的小型神经元的突触前代谢型GABAB受体介导。为了探讨肽能和非肽能2个亚群的小型背根神经节(DRG)神经元是否在痛觉调制过程中发挥同等作用,本实验用免疫荧光组织化学法和激光共聚焦显微镜技术观察了DRG内肽能和非肽能2个亚群的小型神经元中GABAB受体的表达。结果显示:92%的肽能和90%的非肽能亚群的小型神经元均表达GABAB受体,这些受体存在于2个亚群的胞体及其分布在脊髓背角特定板层的中枢突中。该结果表明在痛觉调制过程中,肽能和非肽能2个亚群的小型DRG内神经元在脊髓水平发挥类似作用,但作用于脊髓背角的不同板层。
It is known that one of the pathways of modulation of pain delivery is mediated by presynaptic metabotropic GABAB receptors of small neurons in the dorsal root ganglion. In order to investigate whether the small DRG neurons of two subgroups of peptide and non-peptide can play an equal role in the process of pain modulation, we used immunofluorescence histochemistry and laser scanning confocal microscopy to observe whether DRG Expression of GABAB receptors in small neurons of two subgroups, endopeptidase and nonpeptidic. The results showed that 92% of the peptides and 90% of the non-peptide subpopulations of small neurons expressed GABAB receptors, which are present in the two subpopulations of the soma and their distribution in the spinal cord dorsal horn Suddenly. This result indicates that neurons in small DRGs in both DRG and non-peptide 2 subgroups play a similar role at spinal level during pain modulation, but act on different laminae in the dorsal horn of the spinal cord.