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目的:研究血纤溶活性变化对颈动脉粥样硬化患者和急性脑梗死患者的影响。方法:67例急性脑梗死患者(ACI组)和62名健康体检老年人(对照组),均行彩色多普勒超声诊断仪超声观察颈动脉有无斑块;同时测定血浆组织型纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制物-1(PAI-1)的活性。结果:对照组中有颈动脉斑块者与无颈动脉斑块者相比,血浆t-PA降低,PAI-1升高,P/t值升高(P<0.05);观察组颈动脉斑块发生率明显高于对照组(P<0.05);观察组患者急性期血浆t-PA、PAI-1升高,P/t值减少(P<0.05)。结论:颈动脉硬化时,机体纤溶活性处于减低状态;急性脑梗死发生时,纤溶活性处于相对亢进状态。
Objective: To study the changes of fibrinolytic activity in patients with carotid atherosclerosis and acute cerebral infarction. Methods: 67 patients with acute cerebral infarction (ACI group) and 62 healthy control subjects (control group) were examined by color Doppler ultrasonography with or without carotid artery plaque. The levels of plasma tissue plasmin (T-PA) and plasminogen activator inhibitor-1 (PAI-1) activity. Results: Compared with those without carotid artery plaque in control group, plasma t-PA decreased, PAI-1 increased, P / t increased (P <0.05) (P <0.05). The levels of plasma t-PA and PAI-1 in the observation group were significantly increased and P / t decreased (P <0.05) in the acute phase of the observation group. Conclusion: Carotid atherosclerosis, the body fibrinolytic activity in a reduced state; the occurrence of acute cerebral infarction, fibrinolytic activity in a relatively hypertrophic state.