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矽肺的发生发展受多因素影响,近年来对脂类特别是肺表面活性物质的改变与矽肺发生、发展的关系研究较多,利用支气管肺泡冲洗液(BAL)中磷脂谱的动态变化来判断矽肺病变程度,到目前为止还未见报道。本文旨在观察大鼠实验性矽肺BAL中总磷脂,二棕榈酰卵磷脂(DPPC),磷脂酰甘油三酯(PG)、磷脂酰乙醇胺(PE)含量的动态变化,寻找评价实验性矽肺发生、发展过程中早期病变程度的指标,探讨矽肺发生、发展和肺表面活性物质改变的关系。
The occurrence and development of silicosis are affected by many factors. In recent years, there are many studies on the relationship between the changes of lipids, especially the pulmonary surfactant, and the occurrence and development of silicosis. The use of the dynamic changes of phosphatidylcholine in bronchoalveolar lavage fluid (BAL) The extent of the disease has not been reported so far. This article aims to observe the dynamic changes of total phospholipid, dipalmitoyl lecithin (DPPC), phosphatidylglycerol (PG) and phosphatidylethanolamine (PE) in experimental silicosis of BAL, and to find out the mechanism of experimental silicosis, Development of early lesions in the index to explore the occurrence of silicosis, development and changes in pulmonary surfactant relationship.