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环孢霉素(cyclosporin,CS)最初是在挪威发现。1970年起瑞士Basel市Sa-ndoz有限公司对环孢霉素A(CS-A)作了大量研究。1972年该公司的Jean F Borel博士发现了CS-A的免疫抑制作用。1976年发表报告。1978年应用于临床取得了令人鼓舞的结果。在心脏、肝脏及肾脏移植中,应用CS-A与常用的硫唑嘌呤-泼尼松疗法相比,CS-A同样有效或更为良好。CS-A能显著地提高同种移植物的存活时间,减少排斥反应和严重感染。最突出的表现是降低
Cyclosporin (CS) was originally found in Norway. Since 1970, Sa-ndoz Co., Ltd., Basel, Switzerland has conducted extensive research on cyclosporine A (CS-A). In 1972, the company’s Dr. Jean F Borel discovered the immunosuppressive effects of CS-A. Published a report in 1976. Clinical application in 1978 has yielded encouraging results. In the heart, liver, and kidney transplants, CS-A was equally or better than CSa, compared to commonly used azathioprine-prednisone. CS-A can significantly increase the survival time of allografts, reduce rejection and serious infections. The most prominent performance is to reduce