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为观察用１９２Ｉｒ后装治疗脑胶质瘤间质内放疗的有效性及其并发症，用皮下荷瘤鼠和脑荷瘤鼠模型行间质内放疗实验，证明在内照射后可抑制肿瘤生长及延长鼠的生存期的可靠基础上，对７２例脑胶质瘤采用１９２Ｉｒ后装机行瘤间质内近距离照射，取得良好疗效。手术无何严重并发症，无死亡。术后随访１～５年，生存率分别为９２％、８２％、７２％、５６％及３２％，表明生存期显著延长。结论：脑深部胶质瘤用１９２Ｉｒ核素瘤间质内高剂量率照射可有效抑制肿瘤生长，控制复发，延长生存期是一种可供选择的有效的方法。
In order to observe the effectiveness of 192Ir afterloading treatment of glioma in interstitial radiotherapy and its complications, subcutaneous tumor-bearing mice and brain tumor bearing mice model of interstitial radiotherapy experiments showed that after irradiation can inhibit tumor growth And extend the survival of mice on the basis of reliability, 72 cases of glioma using 192Ir after installation of tumor interstitial brachytherapy, and achieved good results. No serious complications of surgery, no death. Survival rates were 92%, 82%, 72%, 56% and 32%, respectively, after a follow-up of 1 to 5 years, indicating a significant prolongation of survival. Conclusion: Deep brain glioma with high dose rate of 192Ir nuclear interstitum irradiation can effectively inhibit tumor growth, control recurrence and prolong survival is an effective alternative.