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目的探讨缬沙坦对家兔急性心肌梗死KChIP2 mRNA表达量的影响。方法家兔36只,随机等分为手术组、药物组、假手术组;各组按术后1周、4周分成2个亚组。应用逆转录-聚合酶链式反应方法检测各组梗死周围区心肌KChIP2 mRNA的水平。结果手术组和药物组在AMI后1周、4周,KChIP2 mRNA表达量均显著降低(P<0.001)。与手术组相比,药物组1周、4周后KChIP2 mRNA表达量均显著升高(P<0.05)。结论缬沙坦能够提高家兔AMI后KChIP2 mRNA水平。
Objective To investigate the effect of valsartan on the expression of KChIP2 mRNA in rabbits with acute myocardial infarction. Methods Thirty - six rabbits were randomly divided into operation group, drug group and sham operation group. Each group was divided into 2 subgroups according to 1 week and 4 weeks after operation. Reverse transcription - polymerase chain reaction method was used to detect the level of KChIP2 mRNA in myocardial infarction area. Results The expression of KChIP2 mRNA in the operation group and the drug group was significantly decreased at 1 week and 4 weeks after AMI (P <0.001). Compared with the operation group, the expression of KChIP2 mRNA in the drug group was significantly increased after 1 and 4 weeks (P <0.05). Conclusion Valsartan can increase the KChIP2 mRNA level after AMI in rabbits.