论文部分内容阅读
目前用于预防卡氏肺孢子虫肺炎(Pneumocystis carinii Pneumonia,PCP)的药物是甲氧苄氨嘧啶—磺胺甲噁唑(TMP-SMZ)和雾化戊烷脒。但TMP-SMZ的副作用较大,雾化戊烷脒的疗效不太高且价格昂贵,需寻找较理想的药物。氨苯砜(Dapsone)对实验动物PCP及人HIV阳性者的PCP不论在治疗上还是首次预防上都有一定疗效。作者采用多中心随机、非盲抽样法,对氨苯砜预防PCP复发的长期效果及其安全性进行了研究,并与美国FDA推荐的雾化戊烷脒作比较。
The current drugs used to prevent Pneumocystis carinii pneumonia (PCP) are trimethoprim-sulfamethoxazole (TMP-SMZ) and nebulized pentamidine. However, the side effects of TMP-SMZ are larger, and the efficacy of atomized pentamidine is not too high and expensive, so the ideal drug needs to be found. Dapsone is effective in treating both PCP and human HIV-positive PCP both in the treatment and in the prevention of first-time prophylaxis. The authors used a multicenter randomized, non-blind sampling method to study the long-term effects and safety of dapsone in the prevention of recurrence of PCP and to compare with the US FDA-recommended aerosol pentamidine.