A series of new-type nanometer TiO2 modified polyacrylic copolymer sizing agent were synthesized from acrylic acid, ethyl acrylate, nanometer TiO2, oleic acid etc.by orthogonal design method. Results of the studies show that the synthetic method used in this paper was a new way and had never been found in the synthesis of acrylate sizing agent, and that the properties of those new-type size-agent were be improved, which had potential for substituting PVA (polyvinyl alcohol) sizing agent. The technology for solving the problem of nano-scale powder agglomeration and dispersion were also studied. The transmission electron microscope (TEM) observation showed that nano-TiO2 had good dispersion and stability in aqueous solution and in sizing agent solution.