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目的研究基本消灭血吸虫病后结肠、直肠癌死亡情况的长期趋势,探讨血吸虫病是否为结肠、直肠癌的病因。方法通过昆山市(原血吸虫病重流行区)、张家港市(非流行地区)1973～1975年、1981～1983年、1990～1992年和1999～2001年的结肠、直肠癌死亡资料,进行生态学比较和生态学趋势分析。结果4个时期中,昆山市男女结、直肠癌的死亡率和标化死亡率高于张家港市,但与时间呈递减趋势(标化死亡率比);生态趋势研究表明,4个时期中,张家港市结肠、直肠癌死亡率不断上升,但昆山市则未呈现这种上升;昆山市1999～2001年的平均死亡年龄比1973～1975年增加了15.02岁,但张家港仅增加了7.47岁。结论昆山市在基本消灭血吸虫病16年和25年时,结肠、直肠癌的人群分布特征已逐步与非血吸虫病流行区的张家港市趋于一致,我们所设想的消灭或基本消灭血吸虫病结肠、直肠癌(大肠癌)减少,这一病因学的重要条件,因为膳食、营养因素的改变而难以在生态学的比较中反映出来。
Objective To study the long-term trend of the death of colon and rectal cancer after exterminating schistosomiasis and to find out whether schistosomiasis is the cause of colon and rectal cancer. Methods The mortality data of colon and rectal cancer in Kunshan (original schistosomiasis endemic area), Zhangjiagang (non-endemic area) from 1973 to 1975, from 1981 to 1983, from 1990 to 1992 and from 1999 to 2001 were analyzed. Comparison and ecological trend analysis. Results In the four periods, the mortality rate and standardized mortality rate of male and female knots and rectal cancer in Kunshan were higher than those in Zhangjiagang City, but decreased with the time (standardized mortality rate). The ecological trend research indicated that among the four periods, The mortality rate of colon and rectal cancer in Zhangjiagang City kept on rising, but Kunshan City did not show such an increase. The average age of death in Kunshan in 1999-2001 increased by 15.02 years from 1973 to 1975, but only increased by 7.47 years in Zhangjiagang. Conclusion Kunshan City, the basic elimination of schistosomiasis 16 years and 25 years, colon, rectal cancer population distribution characteristics have gradually and non-schistosomiasis prevalence area of Zhangjiagang City tend to be consistent, we envisioned to eliminate or substantially eliminate schistosomiasis colon, The reduction of colorectal cancer (colorectal cancer), an important condition of this etiology, is difficult to reflect in ecological comparisons due to changes in dietary and nutritional factors.