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目的:分析米非司酮配伍雷夫奴尔应用于中期妊娠引产疗效,为临床工作者提供参考。方法:回顾分析自2012年1月至2014年12月期间,我院收治的120例要求终止妊娠的孕妇的临床资料。按孕妇入院先后顺序将其分为观察组(n=60)和对照组(n=60),观察组孕妇口服米非司酮和羊膜腔注射雷夫奴尔药物引产,对照组孕妇羊膜腔注射雷夫奴尔,不采用米非司酮。结果:观察组引产成功率为100%,对照组引产成功率为96.67%(P>0.05)。观察组孕妇的平均宫缩发动时间为用药后(28.36±6.32)h,总产程平均为(10.35±4.23)h,平均出血量为(102±78.25)ml;对照组孕妇的平均宫缩发动时间为用药后(35.76±9.52)h,总产程平均为(14.35±5.61)h,平均出血量为(132±71.23)ml。宫缩发动时间、产程和出血量在组间均有显著性差异(P<0.05)。两组孕妇均无明显的药物不良反应及并发症。结论:米非司酮配伍雷夫奴尔可加速宫缩发动,使产程进展加快,减少出血量。
Objective: To analyze the efficacy of mifepristone combined with Levuole in the induction of labor induced by mid-term pregnancy, and provide a reference for clinicians. Methods: The clinical data of 120 pregnant women who requested termination of pregnancy from January 2012 to December 2014 were retrospectively analyzed. The pregnant women were divided into the observation group (n = 60) and the control group (n = 60) according to the order of their admission. The mifepristone and amniotic injection of Levulin were induced in the pregnant women in the observation group. The pregnant women in the control group were injected intra- Leifuluo, do not use mifepristone. Results: The success rate of induction of labor was 100% in observation group and 96.67% in control group (P> 0.05). The mean duration of labor was (28.36 ± 6.32) h and the average length of labor was (10.35 ± 4.23) h in the observation group. The mean amount of bleeding was (102 ± 78.25) For the medication (35.76 ± 9.52) h, the average total labor was (14.35 ± 5.61) h, the average amount of bleeding was (132 ± 71.23) ml. Uterine contractions time, labor and bleeding in the groups were significantly different (P <0.05). Two groups of pregnant women had no obvious adverse drug reactions and complications. Conclusion: The combination of mifepristone and levofuran accelerates uterine contractions, accelerating the progress of labor and reducing the amount of bleeding.