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活体动物止血模型直观、准确,是判断止血药有效性的重要方法。以兔为实验动物的止血模型兼有批量筛选、指标观察及功效验证方面的综合优势,可以满足多种需求。为促进兔止血模型的规范化和止血药动物研究平台的构建,本文通过评估35篇文献,概述了当前兔止血模型在实验材料、实验指标及实验模型的特点。1兔止血模型实验材料评估1.1实验动物文献报道多为健康成年家兔,雌雄不限,个别选用雄性家兔[1]。体质量多在1.3 kg[2]~4 kg[3],多为(2.
Intact animal hemostatic model is intuitive and accurate, is an important method to determine the effectiveness of hemostatic. Rabbit experimental animal hemostatic model both batch screening, observation and efficacy indicators to verify the comprehensive advantages, to meet a variety of needs. In order to promote the standardization of hemostatic rabbit model and the establishment of a hemostatic animal research platform, this paper summarizes the characteristics of the current rabbit hemostasis model in experimental materials, experimental indexes and experimental models by evaluating 35 literatures. Rabbit hemostasis model experimental material evaluation 1.1 Experimental animals Mostly reported in the literature for healthy adult rabbits, male or female, individual selection of male rabbits [1]. Body mass more than 1.3 kg [2] ~ 4 kg [3], mostly (2.