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目的:探讨Survivin与L ivin在子宫内膜异位症中的表达与意义。方法:收集80例因子宫腺肌症行子宫切除术的子宫在位内膜标本为实验组,同期因子宫肌瘤行子宫切除的子宫在位内膜标本45例为对照组。免疫组织化学法检测Survivin、L ivin蛋白的表达,将检测结果进行相关分析。结果:EM s在位内膜中Survivin与L ivin的表达均明显强于对照组,差异有统计学意义(P<0.05)。结论:内异症患者的子宫内膜本身即不同于正常内膜,对凋亡易感性低,随经血逆流到盆腔后具有存活能力,能够逃避盆腔中多种凋亡诱导信号的刺激,易于形成异位灶,同时致使子宫内膜组织向子宫肌层浸润,易于形成子宫腺肌症。
Objective: To investigate the expression and significance of Survivin and L ivin in endometriosis. Methods: 80 cases of adenomyosis due to hysterectomy in the uterus intima endometrium specimens for the experimental group, the same period due to uterine fibroids hysterectomy eutopic endometrial specimens of 45 cases as the control group. Immunohistochemistry was used to detect the expression of Survivin and Livin, and the correlation analysis was carried out. Results: The expressions of Survivin and Livin in EM s eutopic endometrium were significantly higher than those in control group (P <0.05). Conclusion: The endometrium of patients with endometriosis is different from the normal endometrium, which has low susceptibility to apoptosis. It has the ability to survive after the blood flows back to the pelvis and can evade the stimulation of various apoptosis-inducing signals in the pelvis and is easy to form Ectopic foci, while causing endometrial tissue infiltration into the myometrium, easy to form adenomyosis.