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OBJECTIVE:To explore the effect of antithymocyte globulin(ATG)/antilymphocyte globulin(ALG) plus kidney-nourishing Chinese medicinal(KNCM) on severe aplastic anemia(SAA).METHODS:Twenty-five subjects of severe aplastic anemia were treated with ATG/ALD plus KNCM between 1992 and 2009,and the clinical data before and after treatment were collected and analyzed.RESULTS:Of the 25 patients,9 were nearly cured,6 were improved,5 were in remission,and 5 failed.The overall effective rate was 80.0%.The 3-year,5-year,10-year,15-year survival rate were respectively 98.6%,97.3%,97.3%,67.5%,and median survival time was 180 months.Compared to the conditions before administering the medication of ATG/ALG plus KNCM,after 2 weeks,reticulocyte was first improved(P=0.001);one month later,followed by palette(P=0.037);two months later,by neutrophil cell in peripheral blood(P=0.001);three months later,then by the hemoglobin(P=0.012).By conducting 1-year follow-up,1 case of complication-paroxysmal nocturnal hemoglobinuria(PNH) was identified and the patient still alive today.CONCLUSION:ATG/ALG plus KNCM had better effect on SAA and could improve patients’ survival rate.
OBJECTIVE: To explore the effect of antithymocyte globulin (ATG) / antilymphocyte globulin (ALG) plus kidney-nourishing Chinese medicinal (KNCM) on severe aplastic anemia (SAA). METHODS: Twenty-five subjects of severe aplastic anemia were treated with ATG / ALD plus KNCM between 1992 and 2009, and the clinical data before and after treatment were collected and analyzed. RESULTS: Of the 25 patients, 9 were nearly cured, 6 were improved, 5 were in remission, and 5 failed. year-old, 15-year survival rates were respectively 98.6%, 97.3%, 97.3%, 67.5%, and median survival time was 180 years. Compared to the conditions before administering (P = 0.001); one month later, followed by palette (P = 0.037); two months later, by neutrophil cell in peripheral blood (P = 0.001 ); three months later, then by the hemoglobin (P = 0.012) .By conducting 1-year follow-up, 1 case of complication-paroxysmal nocturnal he moglobinuria (PNH) was identified and the patient still alive today. CONCLUSION: ATG / ALG plus KNCM had better effect on SAA and could improve patients’ survival rate.