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目的 探讨付氧酶 1(PON1)A191B基因多态性与单纯Ⅱ型糖尿病及Ⅱ型糖尿病合并脑梗死(CI)的关系。方法 应用聚合酶链式反应 (PCR)法 ,检测 72名正常人 (对照组 )、42例单纯Ⅱ型糖尿病、45例Ⅱ型糖尿病并CI患者PON1A191B基因型。结果 对照组PON1191基因B多态性频率与单纯Ⅱ型糖尿病患者 (0 .6 3)没有相关关系 ;而与Ⅱ型糖尿病并CI患者 (0 .78)显著相关 (P <0 .0 5 )。结论 糖尿病并CI患者PON1191B基因频率明显增高 ,B基因突变可能是Ⅱ型糖尿病并发CI的危险因素之一
Objective To investigate the relationship between PON1 A191B polymorphism and type Ⅱ diabetes and type Ⅱ diabetes complicated with cerebral infarction (CI). Methods Polymerase chain reaction (PCR) was used to detect 72 PON1A191B genotypes in 72 normal subjects (control group), 42 simple type II diabetes mellitus patients and 45 type Ⅱ diabetes mellitus patients with CI. Results The frequency of polymorphism of PON1191 gene B in the control group was not correlated with patients with type Ⅱ diabetes mellitus (0.63), but with type Ⅱ diabetes mellitus (CI 0.78) (P <0.05). Conclusions The frequency of PON1191B gene in patients with diabetes mellitus and CI is significantly higher. Mutation of B gene may be one of the risk factors of type Ⅱ diabetes mellitus complicated with CI