目的观察比较埃索美拉唑与奥美拉唑治疗胃溃疡的临床效果及安全性。方法选择本院2011年1月~2013年6月经胃镜证实的胃溃疡患者96例,根据治疗方法不同分为观察组和对照组,每组48例,观察组采用埃索美拉唑进行治疗,对照组采用奥美拉唑进行治疗,3周后比较两组疗效及安全性。结果观察组有效率为95.83%,与对照组的81.25比较,明显增高,差异有统计学意义(P<0.05);观察组并发症发生率为8.33%,较对照组的6.25%比较,差异无统计学意义(P>0.05)。结论埃索美拉唑治疗胃溃疡临床效果优于奥美拉唑,安全性高,值得在临床上广泛应用。 Objective To compare the clinical efficacy and safety of esomeprazole and omeprazole in the treatment of gastric ulcer. Methods 96 patients with gastric ulcer confirmed by gastroscopy from January 2011 to June 2013 in our hospital were divided into observation group and control group according to different treatment methods. Each group had 48 cases. The observation group was treated with esomeprazole, The control group was treated with omeprazole, and the efficacy and safety of the two groups were compared after 3 weeks. Results The effective rate of the observation group was 95.83%, which was significantly higher than that of the control group (81.25%) (P <0.05). The incidence of complications in the observation group was 8.33%, compared with 6.25% in the control group Statistical significance (P> 0.05). Conclusion The clinical efficacy of esomeprazole in the treatment of gastric ulcer is better than omeprazole, which is safe and should be widely used clinically.