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[目的]评价毒死蜱对花姬蛙胚胎的致畸效应。[方法]采用两栖动物胚胎致畸(FETAX)试验研究毒死蜱对花姬蛙胚胎的致畸效应。[结果]毒死蜱可引起花姬蛙胚胎脊索弯曲、皮肤色素减少、头部缩小等畸形现象。随着毒死蜱暴露剂量的增加,总畸形率和3种畸形百分比随之增加,呈现出浓度-效应关系。毒死蜱对花姬蛙胚胎96 h-LC_(50)为1.97 mg a.i./L,96 h-EC_(50)为1.00 mg a.i./L,致畸指数TI=1.97。[结论]毒死蜱对花姬蛙胚胎具有潜在致畸风险。
[Objective] To evaluate the teratogenic effects of chlorpyrifos on embryo of Gijon frog. [Method] The amphibian embryo teratogenicity (FETAX) test was used to study the teratogenic effects of chlorpyrifos on embryo of Gijon. [Result] Chlorpyrifos caused the deformity of chordate embryo such as chordal curvature, skin pigmentation and head shrinkage. With the increase of dose of chlorpyrifos exposure, the total deformity rate and the percentage of three kinds of deformity increased with the dose-effect relationship. The chlorpyrifos 96 h-LC50 (50) was 1.97 mg a.i./L for 96 h-EC 50 and 1.00 mg a.i./L for 96 h EC-50, and the teratogenic index TI was 1.97. [Conclusion] Chlorpyrifos has a potential teratogenicity risk on embryo of Gijon frog.