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目的分析血清胱抑素C(Cys-C)检测用于诊断糖尿病早期肾损害的临床意义,为临床早期发现糖尿病肾损害选择敏感、可靠的检测指标。方法 48例2型糖尿病早期肾损害患者作为糖尿病肾病(DN)组,选取同期30例健康体检者作为正常对照组。分别检验两组受试者的血清Cys-C和血清肌酐(Scr)水平。结果 DN组血清Cys-C和Scr水平明显高于正常对照组,两组比较差异有统计学意义(P<0.05)。血清Cys-C对于糖尿病早期肾损害诊断的敏感性、特异性、准确性及阴性预测值均明显高于Scr,比较差异有统计学意义(P<0.05)。结论血清Cys-C检测,因为其敏感性及可靠性高,且操作简便,价格低廉,可以更敏感的反映早期肾损害过程,所以可以作为临床诊断糖尿病早期肾损害的重要指标在临床推广使用。
Objective To analyze the clinical significance of serum cystatin C (Cys-C) in the diagnosis of early diabetic nephropathy and to select sensitive and reliable indicators for early detection of diabetic nephropathy. Methods 48 cases of type 2 diabetic patients with early renal damage as diabetic nephropathy (DN) group, 30 healthy subjects were selected as the normal control group. Two groups of subjects were tested for serum Cys-C and serum creatinine (Scr) levels. Results Serum levels of Cys-C and Scr in DN group were significantly higher than those in normal control group, with significant difference between the two groups (P <0.05). The sensitivity, specificity, accuracy and negative predictive value of serum Cys-C in the diagnosis of early diabetic nephropathy were significantly higher than those in Scr, with significant difference (P <0.05). Conclusion The serum Cys-C test can be used clinically as an important clinical indicator to diagnose the early stage of diabetic nephropathy because of its high sensitivity and reliability, simple operation and low cost. It can reflect the process of early renal damage more sensitively.